What is Tesamorelin?
- Tesamorelin is a synthetic version of growth hormone–releasing hormone (GHRH) that is studied for its ability to stimulate the body’s natural production of growth hormone and increase IGF-1 levels.
- Instead of providing growth hormone directly, Tesamorelin encourages the body to release its own, which research suggests may support fat metabolism, muscle maintenance, and tissue repair. It has drawn particular interest in studies focused on reducing visceral (deep abdominal) fat, where clinical research has shown reductions in abdominal fat while preserving lean muscle mass.
What Studies Have Found
Helps Maintain Lean Muscle
Studies suggest fat loss associated with Tesamorelin typically does not reduce muscle mass, helping preserve lean body tissue.
Encourages Natural Growth Hormone Release
By mimicking the body’s natural growth hormone signals, Tesamorelin supports steady and consistent growth hormone activity rather than short spikes.
Increased IGF-1 Levels
Tesamorelin has been shown to increase IGF-1 levels, which play a role in muscle growth, tissue repair, and recovery.
Reduction of Deep Abdominal Fat
Research shows Tesamorelin may help reduce visceral fat—the deep belly fat linked to metabolic and heart-related concerns.
Potential Side Effects
- Injection Site Reactions – Redness, itching, or mild swelling where the peptide is administered.
- Joint or Muscle Pain – Some research participants have reported stiffness, soreness, or aches due to elevated GH/IGF-1 activity.
- Water Retention & Edema – Fluid buildup in the hands, feet, or ankles has been observed in some studies.
- Headaches – Possibly linked to changes in GH or IGF-1 levels.
- Numbness or Tingling – Reported in the extremities, similar to carpal tunnel–type symptoms, due to GH-related nerve sensitivity.
- Fatigue or Insomnia – Some studies note altered energy levels or changes in sleep patterns during early use.
- Insulin Sensitivity Changes – Research suggests GH/IGF-1 stimulation may alter glucose control in certain individuals, though findings are dose-dependent.
- Rare but Serious Risks – Long-term studies continue to evaluate whether Tesamorelin could contribute to abnormal tissue or tumor growth due to its IGF-1 elevating effects.