What is Semax?
- Semax is a synthetic peptide that was originally developed in Russia for brain and nervous system research. It is based on a small fragment of adrenocorticotropic hormone (ACTH) but has been modified to remove hormonal effects while keeping its beneficial neuroactive properties.
- Semax has also been studied for its antioxidant and anti-inflammatory properties, particularly in research models involving reduced blood flow to the brain, traumatic brain injury, and neurodegenerative conditions.
What Studies Have Found
Cognitive Enhancement
Including working memory, attention span, learning acquisition, memory consolidation, and information processing speed.
Neuroprotection
Potential to reduce cell death, preserve neuronal integrity, and maintain cellular function in the face of metabolic stress,
Stress Response
Investigation of its effects on stress hormone regulation, behavioral adaptation, emotional resilience, and the preservation of cognitive function under stress
Neurological Injury Recovery
Potential to reduce infarct size, limit secondary damage cascades, support functional recovery, and promote tissue repair
Potential Side Effects
- Mild Nasal Irritation – As Semax is primarily studied via intranasal administration, some participants experience dryness or irritation in the nasal passages.
- Headaches – Rare reports of mild headaches or pressure sensations following dosing.
- Restlessness or Insomnia – Some anecdotal and clinical observations indicate increased alertness, which may temporarily affect sleep in sensitive individuals.
- Irritability or Mood Changes – Rare mood fluctuations have been reported, potentially due to neurotransmitter modulation.
- Theoretical Long-Term Effects – Long-term data are limited, and as with many neuroactive peptides, prolonged use is still under investigation.