What is Semaglutide?
- Semaglutide is a GLP-1 receptor agonist, meaning it mimics the hormone glucagon-like peptide-1 (GLP-1) that is naturally released in the gut after eating. GLP-1 plays a key role in regulating blood sugar, appetite, and digestion. Semaglutide binds to GLP-1 receptors in the brain, pancreas, and digestive system, helping coordinate how the body responds to food intake.
- One of its primary actions is appetite regulation. Semaglutide activates satiety centers in the brain (particularly in the hypothalamus), which increases feelings of fullness and reduces hunger and food cravings. At the same time, it slows gastric emptying, meaning food stays in the stomach longer, further reinforcing fullness and reducing calorie intake. These combined effects are why semaglutide is strongly associated with weight loss in clinical studies.
What Studies Have Found
Reduces Cardiovascular Risk
Semaglutide may lower the risk of heart-related events by improving blood pressure, cholesterol, and overall metabolic health.
Improves Blood Sugar Control
It helps the body release insulin when needed and lowers excess glucose production, supporting healthier blood sugar levels.
Enhances Metabolic Health
By improving insulin sensitivity and reducing excess body fat, semaglutide supports better overall metabolic function and energy balance.
Supports Weight Loss
Semaglutide reduces hunger and increases feelings of fullness, helping people eat less and maintain a calorie deficit over time.
Potential Side Effects
- Nausea – The most common side effect, especially when starting or increasing the dose, as digestion slows.
- Vomiting – Can occur if nausea is more intense or food intake is too large.
- Diarrhea – Changes in digestion may lead to loose stools for some people.
- Constipation – Slower stomach emptying can reduce bowel movement frequency.
- Stomach Pain or Bloating – Caused by delayed digestion and gas buildup.
- Decreased Appetite – Often expected, but may feel uncomfortable at first.
- Fatigue – Reduced calorie intake or metabolic adjustment can cause low energy early on.
- Dizziness – May occur due to lower blood sugar or reduced food intake.
- Acid Reflux or Heartburn – Slower digestion can increase gastric pressure.
- Injection Site Reactions – Mild redness, itching, or irritation where injected.