What is MOTS-c?
- MOTS-c is a peptide produced inside the mitochondria—the part of the cell responsible for energy production—and is encoded by mitochondrial DNA. Unlike most peptides that come from the cell nucleus, MOTS-c originates directly in the mitochondria, allowing it to play a direct role in how cells manage and use energy.
- MOTS-c helps regulate the AMPK pathway, which is involved in controlling glucose use, fat burning, and overall energy balance. Research has focused on its potential role in improving metabolic flexibility, supporting physical performance, and addressing age-related changes in metabolism, making it a key area of interest in longevity and metabolic health studies.
What Studies Have Found
Studied for Longevity & Healthy Aging
Because MOTS-c levels naturally decline with age, it is being researched for its potential role in maintaining youthful metabolic function and supporting healthy aging.
Promotes Fat Utilization & Weight Balance
Research suggests MOTS-c supports fat burning and may help limit weight gain, even in high-fat dietary conditions.
Physical Performance & Recovery
Animal studies suggest MOTS-c may improve endurance and recovery by helping the body use fuel more efficiently during intense activity.
Metabolic & Glucose Balance
Research shows MOTS-c may help improve how muscles absorb glucose and respond to insulin, making it a key focus in metabolic health studies.
Potential Side Effects
- Injection Site Irritation – Mild redness, itching, or swelling at the injection site may occur.
- Temporary Fatigue or Headache – Some research models report transient fatigue, headache, or mild nausea post-administration.
- Metabolic Fluctuations – As MOTS-c strongly influences energy pathways, blood sugar levels and metabolic markers may temporarily shift in research settings.
- Limited Long-Term Data – Long-term safety and effects remain under investigation, as research is primarily preclinical.