What is 5-Amino-1MQ
- 5-Amino-1MQ (5-amino-1-methylquinolinium) is a small molecule compound that functions as an inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme involved in cellular metabolism and energy regulation. Unlike peptides, it's a synthetic organic compound that has gained attention in metabolic and longevity research.
- 5-Amino-1MQ works by blocking NNMT activity, which leads to increased levels of nicotinamide (a form of vitamin B3) within cells. This elevation in nicotinamide can boost NAD+ production, a critical coenzyme involved in cellular energy metabolism, mitochondrial function, and DNA repair.
What Studies Have Found
Increases NAD+ Levels and Cellular Energy
Elevated NAD+ levels support mitochondrial function, enhance ATP production, and improve overall cellular energy metabolism.
Enhances Metabolic Rate
5-Amino-1MQ may increase resting metabolic rate by improving mitochondrial activity and cellular energy expenditure.
Reduces Visceral Fat Storage
Animal studies have shown 5-Amino-1MQ specifically targets visceral adipose tissue, the dangerous fat stored around internal organs.
Anti-Aging and Longevity Pathways
By increasing NAD+ availability, 5-Amino-1MQ may activate sirtuins and other longevity-associated proteins that support DNA repair, cellular stress resistance, and healthy aging processes.
Potential Side Effects
- Injection site reactions – Redness, swelling, pain, or irritation where injected
- Fatigue – Some users report tiredness, especially during initial use
- Headaches – Mild to moderate headaches have been reported
- Nausea – Digestive discomfort in some individuals
- Flushing – Temporary warmth or redness, possibly related to increased NAD+ metabolism
- Changes in energy levels – May cause fluctuations as metabolism adjusts
- Altered appetite – Some report changes in hunger signals
- Sleep disturbances – Possible due to metabolic changes and energy shifts
- Mild dizziness – Especially when starting treatment